TABLE 1.
Killing activity of daptomycin at 8 μg/ml in calcium-supplemented MHB
| Isolate | Mean log10 CFU/ml (SD) of surviving bacteriaa at:
|
|||
|---|---|---|---|---|
| 0 h | 4 h | 8 h | 24 h | |
| SA0616 | 6.70 (0.26) | 2.21 (0.33) | 1.62 (0.04) | 1.92 (0.51) |
| SA0621 | 6.61 (0.16) | 2.14 (0.36) | 2.05 (0.67) | 3.12 (1.18)* |
| SA0701 | 6.62 (0.20) | 3.39 (0.05)** | 2.00 (0.26) | 2.10 (0.89) |
| S. aureus ATCC 29213 | 6.48 (0.26) | 2.91 (0.21) | 1.6 (0) | 1.6 (0) |
a
Means and standard deviations were calculated from data on six experiments. The level of detection of the assay is to a log10 CFU/ml of 1.6. *, P = 0.045 versus SA0616 at 24 h using the Wilcoxon two sample test; **, P = 0.002 versus SA0616 and SA0621 at 4 h using the Wilcoxon two-sample test.