TABLE 2.
Measured mean pharmacokinetics of antibiotics applied to the in vitro pharmacodynamic modela
Antibiotic | Isolate(s) evaluated | Cmax (μg/ml) | Cmin (μg/ml) | t1/2 (h) | AUC at 24 h (μg/ml·h) |
---|---|---|---|---|---|
Vancomycin | SA0616 | 43.2 | 6 | 7.4 | 98 |
Daptomycin | SA0616, SA0621, SA0629, SA0701 | 99.6 | 13.7 | 8.7 | 1,267 |
Rifampin | SA0629 | 6.7 | 0.49 | 3.4 | 98 |
Cmax, maximum concentration; Cmin, minimum concentration; t1/2, half-life; AUC, area under the concentration-time curve.