TABLE 3.

Variation in echinocandin MIC profiles by geographic region

Region(s) and species	No. of isolates tested	Antifungal agent	No. of isolates for which the MIC (μg/ml) was:
			0.007	0.015	0.03	0.06	0.12	0.25	0.5	1	2	4	≥8
Asia-Pacific
C. albicans	547	Anidulafungin	32	136	195	128	49	4		1	2
		Caspofungin	12	139	228	148	16	3	1
		Micafungin	63	351	108	21			2	2
C. parapsilosis	153	Anidulafungin			1			1	5	44	96	6
		Caspofungin		1		6	9	65	55	9	8
		Micafungin		1				5	34	91	22
C. glabrata	81	Anidulafungin			6	55	18	2
		Caspofungin		8	56	16	1
		Micafungin	16	55	8		2
C. tropicalis	136	Anidulafungin	5	26	67	34	4
		Caspofungin	2	48	58	24	3	1
		Micafungin	7	38	60	23	5	3
C. krusei	9	Anidulafungin			4	5
		Caspofungin				7	2
		Micafungin			1	6	2
C. guilliermondii	7	Anidulafungin					1			1	4	1
		Caspofungin			1			2	3	1
		Micafungin				1		1	3	2
C. lusitaniae	6	Anidulafungin					2	3	1
		Caspofungin					3	3
		Micafungin				1	4	1
C. kefyr	1	Anidulafungin					1
		Caspofungin		1
		Micafungin				1
C. famata	8	Anidulafungin		1	1					2	4
		Caspofungin		1		1	1	4	1
		Micafungin			2				3	1	2
Latin America
C. albicans	533	Anidulafungin	34	134	185	134	42	2			2
		Caspofungin	7	119	249	134	19	5
		Micafungin	57	363	88	23				2
C. parapsilosis	207	Anidulafungin			1			2	10	61	123	10
		Caspofungin			2	5	24	81	77	16	1	1
		Micafungin			1		1	19	50	109	27
C. glabrata	63	Anidulafungin			8	42	12	1
		Caspofungin		4	37	18	4
		Micafungin	8	53	2
C. tropicalis	222	Anidulafungin	5	39	119	47	6	5			1
		Caspofungin	2	61	110	42	5	2
		Micafungin	6	79	91	39	4	2		1
C. krusei	18	Anidulafungin			9	8	1
		Caspofungin				6	7	5
		Micafungin			1	15	2
C. guilliermondii	40	Anidulafungin						2	3	20	10	5
		Caspofungin				1	4	10	17	5			3
		Micafungin					4	2	18	15	1
C. lusitaniae	7	Anidulafungin						3	4
		Caspofungin					2	3	2
		Micafungin					5	2
C. kefyr	7	Anidulafungin			2	3	2
		Caspofungin		7
		Micafungin			4	3
C. famata	8	Anidulafungin				1				2	5
		Caspofungin				1	1	1	4	1
		Micafungin						2	4	2
Europe
C. albicans	1,044	Anidulafungin	47	268	399	268	56	1	1		4
		Caspofungin	12	238	534	230	25	4	1
		Micafungin	108	748	155	25	3	1		4
C. parapsilosis	190	Anidulafungin						4	3	40	124	19
		Caspofungin			1	5	11	71	79	22	1
		Micafungin					1	7	26	111	45
C. glabrata	249	Anidulafungin		1	14	135	91	7		1
		Caspofungin		17	146	69	14	3
		Micafungin	28	199	18	3	1
C. tropicalis	153	Anidulafungin	7	33	87	19	5	1	1
		Caspofungin	3	48	74	24	3	1
		Micafungin	8	60	53	28	3	1
C. krusei	87	Anidulafungin		3	38	36	9		1
		Caspofungin		1		32	31	18	4	1
		Micafungin		2	12	60	9	4
C. guilliermondii	9	Anidulafungin					1		1	3	4
		Caspofungin				1		3	3		2
		Micafungin		1		1		1	4	2
C. lusitaniae	23	Anidulafungin				1	2	6	13	1
		Caspofungin				2	7	11	1	2
		Micafungin			1	1	10	10		1
C. kefyr	22	Anidulafungin			1	10	11
		Caspofungin	2	19	1
		Micafungin			6	16
C. famata	4	Anidulafungin			2					1	1
		Caspofungin			2		1	1
		Micafungin		1	1				2
North America
C. albicans	745	Anidulafungin	64	246	254	128	43	5		1	4
		Caspofungin	18	220	354	145	4	3	1
		Micafungin	114	508	102	14	2		2	3
C. parapsilosis	209	Anidulafungin						2	7	31	147	22
		Caspofungin				5	12	98	72	22
		Micafungin						11	29	106	63
C. glabrata	354	Anidulafungin		2	27	176	132	14	2			1
		Caspofungin		23	196	122	4	3	4	1			1
		Micafungin	50	274	20	6	1	2		1
C. tropicalis	114	Anidulafungin	3	33	49	21	6				2
		Caspofungin	1	29	62	20				1			1
		Micafungin	4	45	34	27	2		1	1
C. krusei	22	Anidulafungin		1	9	10	2
		Caspofungin				11	6	3	2
		Micafungin		1	1	17	2	1
C. guilliermondii	5	Anidulafungin								3	2
		Caspofungin						2	2	1
		Micafungin						2	2	1
C. lusitaniae	22	Anidulafungin					3	5	13	1
		Caspofungin			2		10	9	1
		Micafungin				2	13	6	1
C. kefyr	7	Anidulafungin		1		4	2
		Caspofungin	3	4
		Micafungin		2	3	2
C. famata	4	Anidulafungin							1	1	2
		Caspofungin					1	2	1
		Micafungin					1	1	1	1