Figure 4.

Similarity of the pVHL/elongin BC/hCUL-2 complex and the SCF^CDC4 complex. The pVHL/elongin BC/hCUL-2 complex (Upper) consists of hCUL-2, elongins B and C, and pVHL. The SCF^CDC4 complex consists of CDC53 or CUL-A, SKP1, and the F-box protein CDC4, as well as the ubiquitin-conjugating enzyme CDC34. hCUL-2 contains a region at its carboxyl terminus that is highly conserved in all cullins (17). This region in CDC53 mediates the association with the ubiquitin-conjugating enzyme CDC34. The SKP1 protein is a homologue of elongin C. hCUL-2 is a homolog of CDC53.