FIG. 1.
Effect of MBV on CMV CPE. HEL fibroblasts 6 days after infection at a multiplicity of infection of 0.2 were photographed at an original magnification of ×20 with phase contrast. (A) Control strain T2233 without MBV, showing normal (type 1) CPE. (B) Strain T2233 under 0.3 μM MBV, showing UL97-inhibited (type 2) CPE characterized by refractile nuclear inclusions increasing with advancing CPE. (C) Strain T2923 (H411L mutation) showing mixed type 1 and type 2 CPE under 10 μM MBV. (D) Strain T2903 (V353A and H411L mutations), showing advanced type 1 CPE with apoptotic cells but no nuclear inclusions in the presence of 20 μM MBV.