FIG. 4.

Neutrophils dominate cell infiltrates in the CNS of IFNAR^−/− mice. Numbers and composition of brain-infiltrating cells in infected wt and IFNAR^−/− mice analyzed by flow cytometry at the indicated times p.i. (A) Numbers of bone marrow-derived CD45^high cells/brain. (B to E) Percentages of cell subsets within the infiltrating population identified as neutrophils (B), macrophages (C), CD4 T cells (D), and CD8 T cells (E). Data are the means of three experiments (pooled from three mice/group) per time point ± standard errors of the means. Asterisks indicate statistical significance (P ≤ 0.05) in comparison to wt mice.