FIG. 5.
Dose response of N4CT9-gag1 following i.m. inoculation. Mice (n = 5) were primed by i.m. inoculation with ascending doses of N4CT9IN-gag1 and boosted 8 weeks later by i.m. inoculation with the corresponding dose of N4CT9NJ-gag1. T-cell responses in splenocytes and humoral responses in serum were assessed 5 days postboost. Assays were performed as described in the legend of Fig. 3. (A) HIV-1 Gag tetramer responses. (B) HIV-1 Gag IFN-γ ELISPOT responses. (C) HIV-1 Gag in vivo CTL responses. (D) HIV-1 Gag serum antibody responses.