FIG. 2.

Variable pattern of spreading HIV infection in P versus NP clones. (a) Cells were challenged with either 5 ng p24-CA/million cells of X4 strain 2044 or 20 ng/million cells of R5 strain mBaL. R5 infection was conducted in the presence of a cocktail of neutralizing Abs to β-chemokines MIP-1α, MIP-1β, and RANTES (final concentration of each Ab, 1 μg/ml). Data show mean HIV-1 p24-CA levels in three to five replicate experiments over time. (b) Data on ps20 expression in an exceptional resistant clone. Mean peak p24-CA levels (day 8 for X4 virus and day 12 for R5 virus) are summarized along with qRT-PCR values for ps20 mRNA determined in triplicate at the time of infection. PP, partially permissive.