FIG. 2.

Anti-FrCas^E humoral response in FrCas^E-infected, 667-treated mice depleted of CD8⁺ cells. (A) Anti-FrCas^E antibodies in young CD8⁺ cell-depleted mice. Serum anti-FrCas^E antibodies from the mice of Fig. 1A to C were assayed by ELISA. (B) Anti-FrCas^E antibodies in adult CD8⁺ cell-depleted mice. Serum anti-FrCas^E antibodies from the mice of Fig. 1D to F were assayed by ELISA. (C) Anti-FrCas^E antibodies in adult CD8⁺ cell-depleted mice after viral challenge. Infected/treated mice depleted of CD8⁺ cells at the adult age as indicated in Fig. 2B were challenged with FrCas^E. Serum concentrations of anti-FrCas^E antibodies were compared to those of infected/treated/depleted mice that were not challenged. Error bars indicate standard deviations.