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. 2007 Nov 28;82(3):1195–1203. doi: 10.1128/JVI.01692-07

FIG. 2.

FIG. 2.

Amino acid changes corresponding to MVMp-derived genomes isolated from leukopenic mice. (A) Coding changes found in the consensus sequences of MVM populations present in organs (K, kidney; L, liver; S, spleen; I, intestine) isolated at 14 to 18 wpi from leukopenic SCID mice infected with the I362S (mice S1 to S5) and K368R (mice R6 to R8) variants. Genetic differences between the isolated populations and their respective I362S or K368R parent are outlined. (B) Clonal analysis of the MVM genome composition in spleens of leukopenic mice. The plaque heterogeneity of the S5 and R6 populations is shown above the coding changes localized in the region corresponding to nt 3726 to 4670 of the MVM genome as determined from isolated plaques (PFU) or molecular clones. Genetic changes with respect to the consensus sequence (shadowed) corresponding to viral DNA isolated from the spleens are indicated. n, number of clones with the same genotype. Single letters separated by slashes represent amino acid heterogeneity at this position in the sampled population. Dashes represent amino acids identical to those in the consensus sequence.