FIG. 4.

Kinetics of peripheral blood leukocytes in infected SCID mice. Two mice per each of the indicated MVMp genotypes were intravenously inoculated with 10¹⁰ gradient-purified virions/mouse, a dose equivalent to 2 × 10⁵ PFU for the wild-type MVMp. The numbers of leukocytes (WBC) per milliliter of blood determined for each mouse over the wpi are shown. Endpoints of curves before the 17-wpi time point indicate the time of death. WT, wild type; K368R, K368R variant; K368R/A551V/V575A, RVA virus.