FIG. 5.

Fitness of leukopenia-associated MVMp populations in culture. MVM populations harvested from the livers of leukopenic mice infected with the recombinant I362S (S5 mouse), K368R (R6 mouse), or K368R/A551V/V575A (RVA1 and RVA2 mice) viruses were inoculated onto monolayers of NB324K human fibroblasts, and low-molecular-weight DNA isolated at the indicated hours postinfection (hpi) was sequenced across the region from nt 3736 to 4687 of the MVM genome. Amino acid changes with respect to the MVM consensus sequence in the respective sampled organ (shadowed) are indicated. G/E indicates that G321 was more prevalent than E321, and vice versa for E/G.