TABLE 1.
Vaccination summary for vaccine recipients, EBV seroconversion, and IM
| Vaccine | Vaccine recipient | EBV seroconversion (wk of test) | IM or asymptomatic | EBV serology
|
||
|---|---|---|---|---|---|---|
| VCA
|
EBNA IgG | |||||
| IgM | IgG | |||||
| Peptide | ||||||
| 5 μg | #01 | No (412) | Negative | Negative | Negative | |
| #02 | Yes (628) | Asymptomatic | Negative | Positive | Positive | |
| #04 | Yes (104) | Asymptomaticd | Low positive | Moderate | Negative | |
| #05 | No (542) | Negative | Negative | Negative | ||
| #06 | No (523) | Negative | Negative | Negative | ||
| #07a | No (520) | Negative | Negative | Negative | ||
| #08a | Yes (104) | Asymptomaticd | Negative | Moderate | Positive | |
| #09b | Yes (26) | Asymptomaticd | Negative | Moderate | Negative | |
| 50 μg | #13 | No (421) | Negative | Negative | Negative | |
| #14c | Yes (8) | ?d,e | Positive | Borderlinef | Negative | |
| Placebo | #03 | No (585) | Negative | Negative | Negative | |
| #10 | No (494) | Negative | Negative | Negative | ||
| #11a | Yes (438) | Asymptomatic | Negative | Borderlineg | Not tested | |
| #12 | Yes (392) | IM, treating doctor notified | ||||
a
Second immunization not given due to high anti-TT antibody titers.
b
Declined second immunization.
c
Second immunization not given due to EBV seroconversion.
d
Lymphocyte count within normal range at time of serology test.
e
Diagnosis unclear, possible mild IM or tonsillitis (see text).
f
Borderline. VCA IgM usually lasts for 1 to 2 months. Anti-EBNA IgG responses usually appear after 2 to 6 months.
g
FLR- and RAK-specific T-cell expansions seen by FACS (data not shown), confirming EBV-positive status.