FIG. 3.
Evaluation of the capacity of ANDV neutralizing antibodies to protect in a respiratory challenge model. Hamsters were challenged i.n. with 2,000 PFU of ANDV on day 0 and monitored for 35 days. (A) Passive transfer of serum on day −1. (B) Passive transfer of serum on day +5. (C) Passive transfer of serum on days −1 and +5. NAb, rabbit 1334 day 102 serum containing ANDV neutralizing antibodies with a 50% PRNT titer of 2,560. Serum was administered undiluted, diluted 1:4, or diluted 1:16. Arrows indicate the days on which antibody was injected s.c.