TABLE 2.
Effects of lysosomotropic agents on infection of the prototype PCV2 strain Stoon-1010 in PK-15, SK, ST, and PPKE cells
| Cell type | % PCV2-infected cells treated witha:
|
||||
|---|---|---|---|---|---|
| NH4Cl | CQ | Monensin | Suramin | PVP | |
| PK-15 | 726 ± 110 | 1,212 ± 34 | 1,100 ± 179 | 237 ± 29 | 73 ± 6 |
| SK | 128 ± 7 | 158 ± 3 | 142 ± 11 | 118 ± 3 | 80 ± 27 |
| ST | 160 ± 28 | 446 ± 50 | 162 ± 56 | 117 ± 5 | 86 ± 17 |
| PPKEb | 313 ± 25 | 611 ± 86 | 352 ± 44 | 109 ± 15 | 90 ± 19 |
a
The numbers of PCV2-infected cells following treatment with lysosomotropic agents are expressed as percentages of the numbers of PCV2-infected cells among the respective untreated cells. The data represent means ± standard deviations of three experiments, with each experiment performed in quadruplicate.
b
PPKE, primary porcine kidney epithelial.