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Location of IN mutations associated with resistance to EVG. EVG in complex with the HIV-1 IN CCD is shown along with the catalytic triad residues (D64, D116, and E152) (green) and a magnesium ion (magenta). Amino acid residues conferring resistance to EVG as primary mutations (T66, E92, F121, Q146, and S147) or as secondary mutations (H51, Q95, E138, and E157) are shown in red and cyan, respectively. The flexible loop (residues 140 to 152) is shown in pink.
