TABLE 1.
Animal | Protein of indicated type recognized by:
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MVA sera
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Dryvax sera
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WR sera
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Membrane | Core | Other | Membrane | Core | Other | Membrane | Core | Other | |
Rabbit | D8*b, H3*, A13*, A14*, B5*, L1*, A34* | F17*, L4*, A4, I1 | O2, D13 | D8*, H3*, A56*, A13*, B5*, A14*, A34*, A33*, A27*, A17*, L1*, F13*, L5 | I1*, F17*, I3*, A4*, L4*, A10*, J1* | H5*, E3*, D13*, A42*, C11*, E2*, WR169*, E1, A11*, F2*, B14*, H6, K1*, WR148*, H7*, A40*, A32*, A22*, A45*, J3 | |||
Macaque | D8*, H3*, B5*, L1*, A13*, A56, A17, F13, A14 | A10*, L4 | A11, D13, H5 | B5*, H3*, D8*, A33*, A17*, A56, A13, L1 | A10*, I1 | WR148*, H5, E2, WR149 | |||
Humanc | H3*, D8*, L1, B5, A14, A13, A34 | A10* | H3*, A13, B5, D8, A17, A33 | A10* | WR148*, H5, A11, D13, E2, B2 |
Listed here are all the antigens recognized by 50% or more of the rabbits, macaques, and humans sampled in this study and ranked in each cell in descending order of average SI. Antigens were scored as positive if the SI was >5,000 after subtraction of the corresponding SI obtained with preimmune serum.
Antigens marked with asterisks were recognized by 100% of the individuals in the group.
The 25 humans sampled after Dryvax vaccination consisted of 13 individuals undergoing primary responses and 12 undergoing secondary responses (10).