TABLE 1.
Tumor development in Syrian golden hamsters following i.p. inoculation with SV40 parental strains and recombinant virusesa
| Viral isolate | No. of tumors/no. of animals | % Tumors | Median time to tumors (wk) (range) |
|---|---|---|---|
| Parental viruses | |||
| 776(1E) | 5/16 | 31 | 33 (29-46) |
| 776(2E) | 3/30 | 10 | 27 (24-41) |
| Baylor(1E) | 10/12 | 83 | 27 (21-30) |
| Baylor(2E) | 1/17 | 6 | 23 |
| 777 | 5/19 | 26 | 35 (21-39) |
| SVCPCb | 18/33 | 54 | 32 (15-52) |
| VA45-54(2E)b | 3/13 | 23 | 26 (23-30) |
| SVPML | 0/16 | 0 | |
| Subtotal | 45/156 | 29 | |
| Recombinant viruses | |||
| 776-CPC(2E) | 1/15 | 7 | 27 |
| 776-Baylor(2E) | 5/15 | 33 | 28 (17-52) |
| 776-VA(2E) | 4/31 | 13 | 32 (26-41) |
| 776-PML(2E) | 1/18 | 6 | 36 |
| CPC-776(1E) | 6/17 | 35 | 30 (15-46) |
| CPC-Baylor(1E) | 7/19 | 37 | 30 (17-40) |
| CPC-VA(1E) | 4/17 | 24 | 36 (22-48) |
| CPC-PML(1E) | 11/19 | 58 | 37 (25-51) |
| Subtotal | 39/151 | 26 | |
| Controls | |||
| TC7 cell lysate | 0/109 | 0 | |
| Uninoculated | 0/78 | 0 |
a
A total of 1 × 107 PFU of each virus was inoculated i.p. into 21-day-old weanling hamsters, and animals were observed for 1 year. Only autopsy-proven tumors are reported; if an animal died and no autopsy was performed, that animal was removed from the group count.
b
Some animals of the SVCPC and VA45-54 groups were described previously (50).