TABLE 1.
Susceptibilities of WT and chimeric viruses to neutralization by MAbs
| MAb | Epitope | IC50 (μg/ml) of MAb for virusa
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SF162 | YU2
|
89.6
|
JRFL
|
HxB2
|
ADA
|
|||||||
| WT | 162V1 | WT | 162V1 | WT | 162V1 | WT | 162V1 | WT | 162V1 | |||
| P1H6 | V1 | 0.4 | — | 0.1 | — | 0.03 | — | 0.7 | — | 0.04 | — | 20 |
| P3C8 | V1 | 0.3 | — | 3 | — | 0.02 | — | 2.5 | — | 0.2 | — | — |
| P4D7 | V1 | 0.9 | — | 7 | — | 0.1 | — | 4 | — | 1 | — | — |
| P3B2 | V1 | 1 | — | 8 | — | 0.3 | — | 1.5 | — | 1 | — | — |
| P3E1 | V3 | 0.2 | — | — | 7 | 0.2 | — | 10 | — | — | — | — |
| 447-52D | V3 | 0.04 | — | 2 | 0.01 | <0.01 | 20 | 0.5 | 0.2 | 0.01 | — | 20 |
| IgGCD4 | CD4bs | 0.04 | 0.6 | 0.04 | 0.01 | 0.01 | 0.03 | 0.01 | 0.02 | <0.01 | 0.8 | 0.6 |
| B12 | CD4bs | 0.01 | 10 | 1 | 0.001 | 0.001 | 0.005 | 0.003 | <0.01 | <0.01 | 1 | 0.5 |
| 2G12 | Glycan | 0.3 | — | — | 0.03 | 0.06 | 0.1 | 0.05 | 0.03 | 0.03 | 0.3 | 0.03 |
a
Bold numbers indicate changes in neutralization susceptibility of at least fourfold. —, 50% inhibition of infection was not observed with the highest MAb concentration tested (20 μg/ml); <0.01, 50% inhibition of neutralization was not reached even at the lowest MAb concentration tested (0.01 μg/ml).