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Cleavage of the tRNA primer in the WT and mutant vectors by HIV-1 RT. Mutations are indicated in bold. The arrows depict the positions of the cleavage. The filled arrows denote more-frequent cleavages. Each of the mutant viruses also gave rise to some aberrant 2-LTR circle junctions. These aberrant junctions were classified according to the nature of the aberration (del is deletion, ins is insertion); these data are shown on the right side of the figure for each of the mutants.
