Skip to main content
PMC home page
The Journal of Biophysical and Biochemical Cytology logoLink to The Journal of Biophysical and Biochemical Cytology
. 1959 Jan 25;5(1):143–151. doi: 10.1083/jcb.5.1.143

Abnormal Intranuclear and Cytoplasmic Formations Associated with a Chemically Induced, Transplantable Chicken Sarcoma

Marlene Friedlaender Binggeli 1
PMCID: PMC2224613  PMID: 13630946

Abstract

Thirty GRCH/15 tumors (a 1, 2, 5, 6-dibenzanthracene-induced chicken sarcoma) were examined in the light and the electron microscope. Associated with the sarcoma were two types of abnormal intranuclear lesions, one in the form of a vacuole, the other as an aggregate containing glycogen. In the electron microscope, one type of lesion observed showed an organized microfibrillar structure. Abnormal cytoplasmic formations occurred as massed clusters of thread-like or tubular material, which gave rise to small bodies with concentric shell structure; similar bodies were found associated with vacuoles.

Full Text

The Full Text of this article is available as a PDF (2.5 MB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BELT W. D., PEASE D. C. Mitochondrial structure in sites of steroid secretion. J Biophys Biochem Cytol. 1956 Jul 25;2(4 Suppl):369–374. [PMC free article] [PubMed] [Google Scholar]
  2. BENEDETTI E. L., BERNHARD W., OBERLING C. Présence de corpuscules d'aspect virusal dans des cellules spléniques et médullaires de poussins leucémiques et normaux. C R Hebd Seances Acad Sci. 1956 Jun 11;242(24):2891–2894. [PubMed] [Google Scholar]
  3. BERNHARD W., BONAR R. A., BEARD D., BEARD J. W. Ultrastructure of viruses of myeloblastosis and erythroblastosis isolated from plasma of leukemic chickens. Proc Soc Exp Biol Med. 1958 Jan;97(1):48–52. doi: 10.3181/00379727-97-23642. [DOI] [PubMed] [Google Scholar]
  4. CARR J. G. The biological behaviour of transplants of the GRCH/15 fowl sarcoma. Br J Cancer. 1953 Mar;7(1):131–136. doi: 10.1038/bjc.1953.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DE HARVEN E. A propos de l'application de certaines colorations histologiques à des tissus fixés par l'acide osmique tamponné et inclus dans le méthacrylate de butyle. C R Seances Soc Biol Fil. 1956 May 28;150(1):63–65. [PubMed] [Google Scholar]
  6. FAWCETT D. W. Observations on the cytology and electron microscopy of hepatic cells. J Natl Cancer Inst. 1955 Apr;15(5 Suppl):1475–1503. [PubMed] [Google Scholar]
  7. FAWCETT D. W., SELBY C. C. Observations on the fine structure of the turtle atrium. J Biophys Biochem Cytol. 1958 Jan 25;4(1):63–72. doi: 10.1083/jcb.4.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HOUCK C. E., DEMPSEY E. W. Cytological staining procedures applicable to methacrylate-embedded tissues. Stain Technol. 1954 Jul;29(4):207–211. doi: 10.3109/10520295409115470. [DOI] [PubMed] [Google Scholar]
  9. LOW F. N. Mitochondrial structure. J Biophys Biochem Cytol. 1956 Jul 25;2(4 Suppl):337–340. doi: 10.1083/jcb.2.4.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MANNWEILER K., BERNHARD W. L'ultrastructure du myxosarcome de Fujinami. Bull Assoc Fr Etud Cancer. 1958 Apr-Jun;45(2):223–236. [PubMed] [Google Scholar]
  11. MOSES M. J. Studies on nuclei using correlated cytochemical, light, and electron microscope techniques. J Biophys Biochem Cytol. 1956 Jul 25;2(4 Suppl):397–406. doi: 10.1083/jcb.2.4.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. OBERLING C., BERNHARD W., VIGIER P. Internal structure of the virus-like particles associated with the Rous sarcoma, and their presence in other neoplastic and normal chicken tissues. Nature. 1957 Aug 24;180(4582):386–387. doi: 10.1038/180386a0. [DOI] [PubMed] [Google Scholar]
  13. PALADE G. E. A study of fixation for electron microscopy. J Exp Med. 1952 Mar;95(3):285–298. doi: 10.1084/jem.95.3.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. PALADE G. E. Studies on the endoplasmic reticulum. II. Simple dispositions in cells in situ. J Biophys Biochem Cytol. 1955 Nov 25;1(6):567–582. doi: 10.1083/jcb.1.6.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. PORTER K. R. Electron microscopy of basophilic components of cytoplasm. J Histochem Cytochem. 1954 Sep;2(5):346–375. doi: 10.1177/2.5.346. [DOI] [PubMed] [Google Scholar]
  16. REBHUN L. I. Electron microscopy of basophilic structures of some invertebrate oocytes. I. Periodic lamellane and the nuclear envelope. J Biophys Biochem Cytol. 1956 Jan 25;2(1):93–104. doi: 10.1083/jcb.2.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SCHULZ H. Elektronenmikroskopische Untersuchungen eines Mammakarzinoms der Ratte. Oncologia. 1957;10(4):307–329. [PubMed] [Google Scholar]
  18. SHELTON E. Hepatomas in mice. I. Factors affecting the rapid induction of a high incidence of hepatomas by o-aminoazotoluene. J Natl Cancer Inst. 1955 Aug;16(1):107–127. [PubMed] [Google Scholar]
  19. SWIFT H. The fine structure of annulate lamellae. J Biophys Biochem Cytol. 1956 Jul 25;2(4 Suppl):415–418. doi: 10.1083/jcb.2.4.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. VIGIER P., CHOUROULINKOV I., OBERLING C., GUERIN M. Reaction leucémique associée au sarcome chimique graffable GRCH/15 de la poule. Bull Assoc Fr Etud Cancer. 1957 Jan-Mar;44(1):135–149. [PubMed] [Google Scholar]
  21. WEISS J. M. Mitochondrial changes induced by potassium and sodium in the duodenal absorptive cell as studied with the electron microscope. J Exp Med. 1955 Dec 1;102(6):783–788. doi: 10.1084/jem.102.6.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. WESSEL W., BERNHARD W. Vergleichende elektronenmikroskopische Untersunchung von Ehrlich- und Yoshida-Ascitestumorzellen. Z Krebsforsch. 1957;62(2):140–162. [PubMed] [Google Scholar]

Articles from The Journal of Biophysical and Biochemical Cytology are provided here courtesy of The Rockefeller University Press

RESOURCES