TABLE 5.

Logistic models

Type of analysis and variablea	P value	Odds ratio
Univariate analysis
Baseline HIV RNA level	0.034	2.9
Baseline CD4 count	0.55	1.12
Sex (female vs male)	0.26	3.57
Subtype B vs non-subtype B	0.82	1.21
Minimum DRV concnb	0.2	0.986
No. of major resistance mutations at baselineb	0.21	0.797
No. of DRV resistance mutations at baselineb	0.63	0.914
No. of associated NRTIsb	0.06	0.441
TMC125	0.13	5.39
T-20	0.82	1.15
Presence of mutations at baseline
Mutation V11Ib	0.94	0.944
Mutation V32I	0.49	1.59
Mutation L33F	0.71	1.23
Mutation I47V/Ab	0.28	0.52
Mutation I50Vb	0.16	0.188
Mutation I54M/Lb	0.017	0.24
Mutation G73S	0.13	3
Mutation L76Vb	0.007	0.05
Mutation I84V	0.039	3.44
Mutation L89V	0.27	2.25
Mutation M46I/L	0.49	1.71
Mutation V82A/F/T/S/L	0.53	1.42
Mutation L90Mb	0.42	0.61
Prior use of PIs
LPVb	0.18	0.412
SQV	0.43	1.75
IDV	0.71	1.32
APVb	0.1	0.28
NFVb	0.5	0.679
ATV	0.08	5.39
TPV	0.65	1.3
No. of PIs used previouslyb	0.75	0.947
Multivariate analysis
Baseline HIV RNA level	0.008	5.59
Mutation L76Vb	0.005	0.024
No. of associated NRTIsb	0.03	0.26

^aTMC125, etravirine; T20, enfuvirtide; LPV, lopinavir; SQV, saquinavir; IDV, indinavir; APV, amprenavir; NFV, nelfinavir; ATV, atazanavir; TPV, tipranavir.

^bFactors associated with a decrease in the risk of DRV resistance mutation selection.