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. 2007 Dec 10;52(2):778–781. doi: 10.1128/AAC.01140-07

TABLE 1.

In vitro activities of caspofungin and micafungin against 1,038 yeast isolates in France (2005-2006)

Species (nb) MIC (μg/ml)a of:
Caspofungin
Micafungin
Range MIC50 MIC90 GMIC Range MIC50 MIC90 GMIC
C. albicans (404) 0.125-4 0.5 0.5 0.38 0.015-1 0.03 0.06 0.03
C. glabrata (157) 0.25-8 0.5 1 0.51 0.015-8 0.03 0.06 0.03
C. parapsilosis (109) 0.5-4 2 2 1.57 0.25-2 2 2 1.47
C. tropicalis (62) 0.25-2 0.5 1 0.60 0.03-2 0.06 0.125 0.08
C. guilliermondii (27) 0.06-2 2 2 1.32 0.5-2 1 2 1.00
C. krusei (21) 0.5-8 1 2 1.10 0.125-4 0.25 0.25 0.27
C. kefyr (21) 0.125-0.5 0.25 0.5 0.27 0.06-0.5 0.125 0.25 0.12
C. haemulonii (12) 0.25-8 1 2 0.89 0.06-0.25 0.25 0.25 0.18
C. lusitaniae (12) 1-2 1 1 1.06 0.06-0.5 0.25 0.5 0.23
C. fermentati (10) 1-2 1 2 1.41 0.25-1 1 1 0.66
Other Candida spp.c (27) 0.125-2 0.5 1 0.68 0.03-1 0.06 1 0.09
Other Ascomycota yeastsd (13) 0.25-16 1 16 1.38 0.03-16 0.25 16 0.29
C. neoformans (158) 1-16 8 16 9.59 2-16 16 16 11.31
Other Basidiomycota yeastse (5) 8-16 16 ND ND 8-16 16 ND ND
a

MICs were determined by the EUCAST method in RPMI medium. High off-scale MICs (>8 μg/ml) were converted to the next higher concentration (16 μg/ml). GMIC, geometric mean MIC; ND, not determined.

b

Number of isolates.

c

Other Candida spp.: C. dubliniensis (n = 7), C. lipolytica (n = 5), C. famata (n = 2), C. pelliculosa (n = 2), C. rugosa (n = 2), C. utilis (n = 2), and one each of C. inconspicua, C. intermedia, C. africana, C. lambica, C. nivariensis, C. norvegensis, and C. sphaerica.

d

Other Ascomycota yeasts: Saccharomyces cerevisiae (n = 8), Geotrichum spp. (n = 2), and Williopsis saturnus, Kodamaea ohmeri, and a Zygosaccharomyces sp. (n =1 each).

e

Other Basidiomycota yeasts: Trichosporon spp. (n = 3) and Rhodotorula mucilaginosa (n = 2).