TABLE 1.

TB resistance-related mutations detected by the QIAplex TB assay and prevalence between pretreated and new cases^a

Drug	Target locus	Nucleotide change	Amino acid change	No. detected	No. of isolates (% detection) recovered from:		P
					New cases (n = 132)	Pretreated cases (n = 64)
INH	katG	AGC→ACC	S315T	28	9 (6.8)	19 (29.7)	0.001
	katG	AGC→AAC	S315N	0
	katG	AGC→ATC	S315I	0
	katG	AGC→AGG	S315R	0
	katG	AGC→GGC	S315G	4	0 (0.0)	4 (6.3)	0.039
	ndh	CGC→TGC	R268H	0
	mabA	−15 C→Tb	NA	9	6 (2.3)	3 (4.7)	0.610
RIF	rpoB	Δ of GAC	Δ at 516	0
	rpoB	GAC→GTC	D516V	1	0 (0.0)	1 (1.6)	0.327
	rpoB	CAC→TAC	H526Y	0
	rpoB	CAC→GAC	H526D	2	1 (0.8)	1 (1.6)	0.545
	rpoB	CAC→CGC	H526R	0
	rpoB	CAC→CCC	H526P	0
	rpoB	TCG→TGG	S531W	0
	rpoB	TCG→TTG	S531L	15	5 (3.8)	10 (15.6)	0.005
STM	rpsL	AAG→AGG	K43R	37	20 (15.2)	17 (26.6)	0.056
	rrs	C→T at 491	NA	5	4 (3.0)	1 (1.6)	0.472
	rrs	C→T at 512	NA	0
	rrs	A→T at 513	NA	3	1 (0.8)	2 (3.1)	0.249
	rrs	C→T at 516	NA	4	1 (0.8)	3 (4.7)	0.103
EMB	embB	ATG→ACA	M306I	5	2 (1.5)	3 (4.7)	0.197
	embB	ATG→ACC	M306I	0
	embB	ATG→ACT	M306I	0
	embB	ATG→GTG	M306V	0

^aNA, not applicable; Δ, deletion.

^bAt the promoter region.