TABLE 3.
Molecular basis of antimycobacterial resistance in phenotypically resistant clinical isolates in the Republic of Georgia
| Phenotype | No. of resistance-related mutations detected | Resistance-related mutations detected (no.) |
|---|---|---|
| INH resistance | 41 | katG S315T (26), katG S315G (4), mabA (5), unknown (6) |
| RIF resistance | 18 | rpoB S531L (14), rpoB D516V (1), rpoB H526D (2), unknown (1) |
| STM resistance | 69 | rpsL K43R (37), rrs 491 C→T (4), rrs 513 A→T (3), rrs 516C→T (4), unknown (21) |
| EMB resistance | 6 | embB M306I (3), unknown (3) |
| INH + RIF resistance (MDR-TB)a | 15 | katG S315T only (1), katG S315T + rpoB S531L (11), katG S315T + rpoB H526D (1), mabA + rpoB D516V (1), rpoB S531L only (1) |
a
INH and RIF resistance-related mutations are listed. Two isolates possessed only INH or RIF resistance single mutations.