TABLE 1.
Interaction of SQ641 with other antimycobacterial drugs against M. tuberculosis, M. smegmatis, and M. avium complex strains
| Organism and drug combination | MIC (μg/ml)
|
ΣFICa | |
|---|---|---|---|
| Alone | In combination | ||
| M. tuberculosis | |||
| SQ641 | 0.5 | 0.25 | 1.0 |
| INH | 0.06 | 0.03 | |
| SQ641 | 0.5 | 0.015 | 0.156 |
| EMB | 1.0 | 0.125 | |
| SQ641 | 0.5 | 0.125 | 0.5 |
| SM | 0.25 | 0.062 | |
| SQ641 | 0.5 | 0.031 | 0.187 |
| SQ109 | 0.25 | 0.031 | |
| M. smegmatis | |||
| SQ641 | 2.0 | 0.25 | 0.25 |
| INH | 8.0 | 1.0 | |
| SQ641 | 2.0 | 1.0 | 0.75 |
| RIF | 8.0 | 2.0 | |
| SQ641 | 2.0 | 0.25 | 0.375 |
| EMB | 0.5 | 0.12 | |
| SQ641 | 2.0 | 1.0 | 1.0 |
| SM | 0.5 | 0.25 | |
| M. avium | |||
| SQ641 | 0.25 | 0.062 | 0.313 |
| EMB | 1.0 | 0.062 | |
| SQ641 | 0.25 | 0.125 | 0.75 |
| CLA | 0.125 | 0.031 | |
| SQ641 | 0.25 | 0.125 | 0.75 |
| AMK | 2.0 | 0.5 | |
a
ΣFIC is synergistic (≤0.5), additive (>0.5 to 2.0), or antagonistic (>4.0).