TABLE 3.
Summary of PK parameters and treatment comparisons for APVa
| Parameter | Value for treatment group
|
Treatment comparison | |
|---|---|---|---|
| FPV-RTV (700/100 mg BID) (historical control) (n = 95) | RFB (150 mg QOD) + FPV-RTV (700/100 mg BID) (n = 15) | ||
| AUC(0-τ) (μg·h/ml) | 34.8 (32.6-37.2) | 47.1 (40.2-55.1) | 1.35 (1.17-1.56) |
| Cmax (μg/ml) | 5.38 (5.06-5.73) | 7.29 (6.43-8.27) | 1.36 (1.18-1.55) |
| Cτ (μg/ml) | 1.97 (1.83-2.13) | 2.32 (1.98-2.72) | 1.17 (0.995-1.39) |
a
Parameters are reported as geometric means (95% confidence interval); treatment comparisons are expressed as geometric least-squares mean ratios (90% confidence interval), comparing the combination to the FPV-RTV treatment alone. Calculations were performed as described in Materials and Methods.