FIG. 2.

Results of single-dose time-kill and PAFE studies of anidulafungin against strains of C. albicans and C. glabrata following three intraperitoneal doses of 1.25, 5, and 20 mg/kg. Each symbol represents the mean organism burden in the kidneys of three mice (six kidneys, plated in duplicate). The error bars represent the standard deviations. The solid symbols represent organism burdens in saline-treated control mice. The hollow horizontal bars represent the duration of time that total anidulafungin concentrations remained above the MIC for the organism. The solid horizontal bars represent the duration of time that free-anidulafungin concentrations remained above the MIC for the organism.