TABLE 1.

In vitro susceptibility of select strains of C. albicans, C. tropicalis, and C. glabrata to anidulafungin and relative fitness of these organisms in the disseminated candidiasis model^a

Organism	MIC1 (μg/ml)	MIC2 (μg/ml)	In vivo growth in control animals over 48 h (log10 CFU/kidney)
C. albicans strains
K-1	0.015	0.12	4.00
98-17	0.03	0.12	4.30
98-210	0.015	0.06	3.50
580	0.015	0.03	3.40
C. tropicalis 98-234	0.015	0.12	3.84
Mean ± SD for C. albicans and C. tropicalis strains			3.81 ± 0.33
C. glabrata strains
570	0.03	0.12	2.45
513	0.06	0.12	2.43
33609	0.03	0.12	2.37
32930	0.06	0.12	1.29
33616	1.0	2.0	1.81
34341	0.12	1.0	1.82
35315	0.25	1.0	0.97
5592	0.06	0.12	2.1
5376	0.03	0.06	2.1
37661	2.0	2.0	0.96
Mean ± SD for C. glabrata strains			1.83 ± 0.54
Mean ± SD for all organisms (range)			2.42 ± 1.06 (0.96-4.30)

^aMIC₁, partial-inhibition end point; MIC₂, complete-inhibition end point.