TABLE 3.
In vitro interaction between FK506 and azoles
| Drug in combination, strain, and median | Nonparametric methoda
|
||||
|---|---|---|---|---|---|
| FICI
|
ΔE model
|
||||
| Mean (range) | Interpretation | ΣSYN (n) | ΣANT (n) | Interpretation | |
| FLC | |||||
| Susceptible | |||||
| CA5 | 2.00 (1.00-2.00) | IND | 16 (7) | −51 (11) | IND |
| CA8 | 1.00 (0.5-1.00) | IND | 31 (16) | −43.2 (33) | IND |
| CA12 | 0.5 (0.25-0.50) | SYN | 103.5 (23) | −45.3 (9) | SYN |
| CA14 | 1.00 (0.50-2.00) | IND | 16.8 (7) | −33.9 (21) | IND |
| CA129 | 0.50 (0.25-0.50) | SYN | 65.6 (8) | −36 (16) | IND |
| Median | 1.00 | 31 | −43.2 | ||
| Resistant | |||||
| CA10 | 0.00 (0.00) | SYN | 1,032 (38) | −55.7 (11) | SYN |
| CA15 | 0.00 (0.00) | SYN | 962.7 (34) | −28.4 (8) | SYN |
| CA16 | 0.00 (0.00-0.03) | SYN | 1,322.4 (49) | −13.5 (14) | SYN |
| CA135 | 0.00 (0.00) | SYN | 956 (42) | −33.4 (10) | SYN |
| CA137 | 0.00 (0.00) | SYN | 1,154.3 (52) | −15.6 (6) | SYN |
| Median | 0.00 | 1,032 | −28.4 | ||
| ITR | |||||
| Susceptible | |||||
| CA5 | 1.00 (0.50-1.00) | IND | 11.8 (4) | −38.4 (15) | IND |
| CA8 | 2.00 (0.50-2.00) | IND | 13.7 (4) | −78.4 (21) | IND |
| CA12 | 0.50 (0.25-0.50) | SYN | 137.6 (29) | −49.7 (16) | SYN |
| CA14 | 1.00 (0.50-1.00) | IND | 33.7 (13) | −54.8 (23) | IND |
| CA129 | 0.25 (0.25-0.50) | SYN | 98.1 (54) | −53 (9) | IND |
| Median | 1.00 | 33.7 | −53 | ||
| Resistant | |||||
| CA10 | 0.00 (0.00) | SYN | 1,384.2 (56) | −33.4 (10) | SYN |
| CA15 | 0.00 (0.00) | SYN | 1,618 (49) | −56.1 (13) | SYN |
| CA16 | 0.00 (0.00)) | SYN | 1,142 (57) | −43.8 (7) | SYN |
| CA135 | 0.00 (0.00) | SYN | 1,512.3 (32) | −4.7 (2) | SYN |
| CA137 | 0.00 (0.00) | SYN | 1,035.2 (38) | −38.1 (13) | SYN |
| Median | 0.00 | 1,384.2 | −38.1 | ||
| VRC | |||||
| Susceptible | |||||
| CA5 | 1.00 (1.00-2.00) | IND | 42.9 (6) | −64.3 (11) | IND |
| CA8 | 1.00 (0.50-2.00) | IND | 91.3 (22) | −6.5 (3) | SYN |
| CA12 | 1.00 (0.50-1.00) | IND | 100.6 (26) | −5.7 (5) | SYN |
| CA14 | 1.00 (0.50-2.00) | IND | 35.4 (21) | −83.2 (18) | IND |
| CA129 | 0.25 (0.25-0.50) | SYN | 89.1 (27) | −32.5 (12) | IND |
| Median | 1.00 | 89.1 | −32.5 | ||
| Resistant | |||||
| CA10 | 0.00 (0.00) | SYN | 1,024 (62) | −3.4 (1) | SYN |
| CA15 | 0.00 (0.00) | SYN | 857.8 (42) | −33.5 (13) | SYN |
| CA16 | 0.00 (0.00) | SYN | 912.1 (44) | −15.6 (6) | SYN |
| CA135 | 0.00 (0.00-0.01) | SYN | 1,328 (52) | −97.4 (23) | SYN |
| CA137 | 0.00 (0.00) | SYN | 764.2 (34) | −28.4 (15) | SYN |
| Median | 0.00 | 912.1 | 28.4 | ||
a
SYN, synergism; ANT, antagonism; IND, indifference. For the FICI model, synergy was defined as a FICI of ≤0.5, antagonism was defined as a FICI of >4.0, and indifference was defined as a FICI of >0.5 to 4 (i.e., no interaction). For the ΔE model, ΣSYN and ΣANT were the sums of the percentages of all statistically significant synergistic and antagonistic interactions. Interactions with <100% statistically significant interactions were considered weak synergism, those with 100 to 200% statistically significant interactions were considered moderate, and those with >200% statistically significant interactions were considered strong.