TABLE 4.

Susceptibility of the M423T mutant replicon and polymerase to AG-021541 and structurally related compounds^a

^aThe susceptibility of the M423T replicon cell line to AG-021541 and related compounds was evaluated in the reporter replicon assay. Cells were exposed to compounds for 3 days before RLuc activity was determined. The susceptibility of the M423T mutant polymerase to AG-021541 and related compounds was evaluated in the HCV polymerase biochemical assay as described in Materials and Methods. Results represent the mean ± standard deviation (4 experiments) or individual values (1 to 2 experiments). Values from each experiment represent the averages of duplicates or triplicates. FC, fold change; ND, not determined; IC₅₀, 50% inhibitory concentration.

^b IU/ml.