FIG. 4.

SbV alteration in gene expression in MDMs as determined by real-time qRT-PCR. The changes in expression levels of EDNRB, HMOX-1, and GCLM were analyzed by real-time RT-PCR of RNA derived from MDMs treated with sodium stibogluconate (200 μg/ml). Changes were normalized to GAPDH expression levels. The amount of mRNA was expressed as the relative change standardized to the expression in control cells in each experiment. Each value represents the mean of the results of two experiments with MDMs from two different donors. *, P < 0.03 compared to mock treatment. “Mock” represents the control without sodium stibogluconate (ratio of GAPDH expression in the presence and absence of sodium stibogluconate).