TABLE 1.
Modulation of gene expression in THP-1 cells by sodium stibogluconate (SbV-containing drug)a
| Protein | Gene symbol | GenBank accession no. | Change (fold) in gene expression mediated by:
|
Function | ||
|---|---|---|---|---|---|---|
| Leishmania | SbV | Leishmania and SbV | ||||
| Selenoprotein W, 1 | SEPW1 | NM_003009 | 0.77 | 0.37 | 0.36 | Unknown |
| Mannose receptor, C type 1 | MRC1 | NM_002438 | 0.65 | 0.41 | 0.42 | Receptor-mediated endocytosis |
| 5′-Nucleotidase, cytosolic II | NT5C2 | NM_012229 | 1.39 | 2.04 | 1.64 | 5′-Nucleotidase activity |
| Apolipoprotein C-I | APOC1 | NM_001645 | 1.77 | 2.07 | 2.32 | Lipid metabolic process |
| Heme oxygenase (decycling) 1 | HMOX1 | NM_002133 | 0.42 | 2.11 | 2.16 | Heme oxygenase (decyclizing) activity |
| Glutamate-cysteine ligase, modifier subunit | GCLM | NM_002061 | 0.91 | 2.20 | 1.94 | Response to drug/oxidative stress |
| Melanoma antigen family B, 2 | MAGEB2 | NM_002364 | 1.51 | 2.37 | 2.19 | Protein binding |
| Endothelin receptor type B | EDNRB | NM_000115 | 0.64 | 4.77 | 4.50 | G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) |
a
Modulation of gene expression in THP-1 cells was measured using an Affymetrix human genome focus array after 4 days of incubation with 200 μg/ml of SbV.