Figure 1.

(a) Ribbon diagram and surface representation of SaGMK, showing the various domains. The NMP domain is coloured yellow, the core domain green, the visible part of the lid domain orange and the C-terminal domain raspberry. (b) Ribbon diagram showing superimposition of the SaGMK and EcGMK dimers. Bound ligands in SaGMK (GMP, sulfate) and the intradimer disulfide bridge are shown in standard atom colours. SaGMK subunits are coloured blue and red, whilst the EcGMK structure is coloured grey.