Table 3.
Gene | Expression during regeneration | Blastema formation |
wg-induced transdeterminations
|
||||
---|---|---|---|---|---|---|---|
Leg-to-wing | Eye-to-wing | Antenna-to-wing | Maxillary palp-to-wing | Genital-to-wing | |||
Kr-h1^ | Blastema-specific | NC | S | S | S | S | NC |
rpd3 | Ubiquitous/blastema | Reduced | S | S | S | NC | NC |
jing^ | Blastema-specific | Reduced | S | S | S | S | S |
cg^ | Blastema-specific | Delayed | S | S | S | S | S |
Aly | Blastema-specific | Delayed | S | S | S | NC | NC |
S6k | Ubiquitous/blastema | NC | E | NC | S | NC | NC |
Six genes were identified that met both criteria of our screen, that is, they displayed expression in the regeneration blastema during leg disc regeneration and significantly modified regeneration-induced leg-to-wing transdetermination. Expression patterns are based on whole-mount in situ hybridization in the leg disc. S, suppresses; E, enhances; NC, no significant change.
Indicates that more than one allele was tested and found to modify wg-induced leg-to-wing transdetermination. All of the genes when heterozygous mutant dominantly modify at least one other (besides leg-to-wing) wg-induced transdetermination event.