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. Author manuscript; available in PMC: 2008 Feb 3.
Published in final edited form as: Am J Physiol Heart Circ Physiol. 2007 Jun 8;293(3):H1689–H1695. doi: 10.1152/ajpheart.00538.2007

Fig. 4.

Fig. 4

Effects of AM251 on load-independent contractile parameters. A: representative pressure-volume (PV) loops obtained with a P-V conductance catheter system at different preloads are shown. Note that the slope of the end-systolic P-V relation (ESPVR) is less steep in cirrhotic compared with control animals, indicating decreased contractile function, and is acutely increased following treatment of the cirrhotic rats with 3 mg/kg AM251. Effect of AM251 on load-independent contractile parameters measured as maximal cardiac elastance (Emax), ESPVR, preload-recruitable stroke work (PRSW) for systolic (B) and end-diastolic P-V relation (EDPVR) for diastolic function (C) (see METHODS) is shown. Control and cirrhotic animals were treated with vehicle (open and shaded bars, respectively) or 3 mg/kg AM251 (solid bars). Values are means ± SE; n = 6–8 rats per group. P < 0.05, *control vs. cirrhotic, or #vehicle vs. AM251 value.