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CB2 agonist limits liver I/R-induced damage, lipid peroxidation, and neutrophil infiltration. (A) Serum transaminase ALT and (B) LDH levels; (C) liver MDA level and (D) MPO activity in sham or in mice exposed to 60/120 min I/R, pretreated with vehicle, HU-308 (10 mg/kg), AM251 (1 mg/kg) + HU-308, or AM630 (1 mg/kg) + HU-308 (n=7–12/each group; *, P<0.05, vs. I/R; #, P<0.05, versus I/R+HU-308).
