CB2 receptor agonist decreases proinflammatory markers in serum and liver. (A and B) TNF-α, MIP-2, and MIP-1α and levels in serum and liver tissue, measured by ELISA in sham or in mice exposed to 60/120 min I/R, pretreated with vehicle, HU-308 (10 mg/kg), or AM630 (1 mg/kg) + HU-308 (n=6–12/each group; *, P<0.05, vs. I/R; #, P<0.05, vs. I/R+HU-308).