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CB2 receptor agonist decreases I/R-induced apoptosis. (A) Caspase 3 activity and (B) DNA fragmentation in sham or in mice exposed to 60/120 min I/R, pretreated with vehicle, HU-308 (10 mg/kg), or AM630 (1 mg/kg) + HU-308 (n=6–8/each group; *, P<0.05, vs. I/R; #, P<0.05, vs. I/R+HU-308).
