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PN activates the phosphorylation of IKKα and NIK. IKKα phosphorylation was monitored in cells stimulated with LPS (A) or TNFα (B) for 10 to 120 min, in the absence or presence of peroxynitrite (PN). In the presence of PN, there was a strong phosphorylation of IKKα, maintained for up to 120 min after LPS or TNFα, with no change in total IKKα. C: PN alone strongly activated the phosphorylation of IKKα and NIK, an effect starting after 10 min. NS: Not Stimulated. NSB: non specific band
