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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Neuropharmacology. 2007 Jul 6;54(1):68–78. doi: 10.1016/j.neuropharm.2007.06.026

Fig. 1. Differential sensitivity of MCF and MPP inputs to group II mGluR agonist DGC-IV.

Fig. 1

(A) Top, example of the typical longitudinal slices used in this study. Bottom, close-up of the region indicated by the white rectangular box in the top photograph showing the positioning of stimulating and recording pipettes. Schematic drawing of the organization of the different pathways in the molecular layer of the dentate gyrus are overlaid on the image. Stimulating electrodes were placed either proximal to the granule cell layer so as to activate fibers from mossy cells (MCF) or more distally (middle third of the molecular layer) to excite the medial perforant path (MPP). GC, granule cell; MC, mossy cell; LPP, lateral perforant path. (B) Time course of average excitatory responses demonstrating the inhibitory effect of DCG-IV on MPP (open squares) but not MCF (filled circles). Top, Representative EPSC traces from an individual experiment obtained at the time points in the time-course graph.