Table 4.

Interaction between MTHFR and MTRR genotypes in women with Down syndrome-affected pregnancies (case mothers) (n=64) and control mothers (n=70)

MTHFR	MTRR	Number (percentage) of case mothers	Number (percentage) of control mothers	Odds ratio	95% CI	P
CC	AA or AG	10 (15.6%)	27 (38.6%)	1.0
TT or CT	AA or AG	26 (40.6%)	26 (37.1%)	2.7	1.091~6.685	>0.05
CC	GG	8 (12.5%)	8 (11.4%)	2.7	0.798~9.140	>0.05
TT or CT	GG	20 (31.3%)	9 (12.9%)	6.0	2.058~17.496	<0.025