Leiomyosarcoma of nipple-areola complex |
More common in female. Solitary slow-growing nodular lesion. May be asymptomatic. Possible origins: smooth muscle bundles surrounding lactiferous ducts, arrector pili muscle at periphery of areola |
Excision, simple, modified radical or radical mastectomy |
2 of the 7 tumors listed above recurred, 1 metastasized |
Leiomyosarcoma of skin other than nipple-areola complex |
More common in men. Peak incidence: the sixth decade. Usually presents as a solitary nodule or plaque on the extensor surfaces of extremities and less commonly on the scalp and trunk. May be painful or asymptomatic. Grow insidiously. Possible origins: arrector pili muscle in the dermis or genital dartos muscle |
Wide local excision with a 3- to 5-cm safe margin |
Local recurrence rates: 30%~50%, rarely metastasize |
Leiomyosarcoma of mammary parenchyma |
More common in female. Average age: 52 years. Slow-growing solitary well-defined nodule. May be asymptomatic. Possible origins: myoepithelium, blood vessels |
Simple mastectomy was recommended by Uğraş et al.(1997) |
Reported to have quite high possibility of recurrences or metastases that occur hematogenously (Markakietal, 2003) |