Skip to main content
. 2008 Feb;9(2):109–113. doi: 10.1631/jzus.B0720246

Table 3.

Summary of the clinical features of primary leiomyosarcoma of various sites reported in literature

Clinical presentation Treatment Outcome
Leiomyosarcoma of nipple-areola complex More common in female. Solitary slow-growing nodular lesion. May be asymptomatic. Possible origins: smooth muscle bundles surrounding lactiferous ducts, arrector pili muscle at periphery of areola Excision, simple, modified radical or radical mastectomy 2 of the 7 tumors listed above recurred, 1 metastasized
Leiomyosarcoma of skin other than nipple-areola complex More common in men. Peak incidence: the sixth decade. Usually presents as a solitary nodule or plaque on the extensor surfaces of extremities and less commonly on the scalp and trunk. May be painful or asymptomatic. Grow insidiously. Possible origins: arrector pili muscle in the dermis or genital dartos muscle Wide local excision with a 3- to 5-cm safe margin Local recurrence rates: 30%~50%, rarely metastasize
Leiomyosarcoma of mammary parenchyma More common in female. Average age: 52 years. Slow-growing solitary well-defined nodule. May be asymptomatic. Possible origins: myoepithelium, blood vessels Simple mastectomy was recommended by Uğraş et al.(1997) Reported to have quite high possibility of recurrences or metastases that occur hematogenously (Markakietal, 2003)