. 2008 Jan 1;31(1):34–44. doi: 10.1093/sleep/31.1.34

Table 2.

Duration of Wake Time and Number of Wake Bouts Observed Per Hour Following Treatment with MDL100907, RO4368554, Zolpidem, and Vehicle

ZT	Vehicle	MDL100907, mg/kg			RO4368554, mg/kg			Zolpidem, mg/kg
ZT	Vehicle	0.3	1.0	3.0	1.0	3.0	10.0	10.0
Wake bout duration
19	6.79 ± 2.36	5.18 ± 1.58	5.60 ± 1.12	4.91 ± 1.45	4.06 ± 0.80	6.41 ± 4.48	7.44 ± 2.73	1.77 ± 0.15
20	3.53 ± 1.43	2.50 ± 0.56	4.42 ± 1.63	5.35 ± 1.72	3.20 ± 1.20	1.38 ± 0.15	2.29 ± 0.57	2.61 ± 0.35
21	2.14 ± 0.29	3.09 ± 1.03	2.00 ± 0.40	2.99 ± 0.61	3.16 ± 0.91	2.94 ± 0.63	4.51 ± 2.05	2.09 ± 0.50
22	2.87 ± 0.81	3.47 ± 1.05	12.89 ± 9.69	2.75 ± 0.70	4.71 ± 1.70	4.93 ± 1.77	4.15 ± 2.38	3.50 ± 0.71
23	5.02 ± 1.08	4.24 ± 0.50	7.64 ± 2.23	2.35 ± 0.44	4.13 ± 1.06	3.14 ± 0.44	4.30 ± 1.77	4.23 ± 0.89
24	4.82 ± 0.83	11.29 ± 6.93	4.96 ± 0.91	4.39 ± 0.94	10.28 ± 3.87	11.96 ± 4.31	17.38 ± 7.24	16.01 ± 7.08
Number of bouts
19	7.00 ± 1.65	5.22 ± 1.06^b	8.78 ± 1.14^b	7.44 ± 1.43^b	9.44 ± 1.30^b	8.33 ± 2.48^b	6.22 ± 1.08^b	17.44 ± 2.03^a
20	19.11 ± 2.47	10.00 ± 1.39^a	10.33 ± 1.55^a	8.56 ± 1.60^a	14.33 ± 1.67	16.89 ± 1.03	14.11 ± 1.44^a	13.11 ± 1.21^a
21	18.78 ± 2.26	9.44 ± 0.82^a^b	10.67 ± 0.88^a^b	12.22 ± 1.54^a	17.11 ± 2.38	16.67 ± 1.91	14.00 ± 2.24	16.22 ± 2.20
22	18.67 ± 2.06	12.44 ± 1.31^a	12.33 ± 2.22^a	11.44 ± 1.59^a	16.22 ± 2.70	15.33 ± 3.14	17.44 ± 2.51	12.78 ± 1.47^a
23	14.78 ± 2.46	12.33 ± 1.42	10.67 ± 1.54	12.56 ± 1.17	13.56 ± 1.97	18.22 ± 3.12	14.78 ± 2.23	14.56 ± 2.24
24	10.67 ± 1.13	12.44 ± 2.01	11.00 ± 1.32	12.00 ± 1.21	9.78 ± 1.90	11.33 ± 2.63	12.33 ± 3.03	11.11 ± 2.66

Data are expressed as mean ± SEM duration of waking, in minutes, and mean number (± SEM) of bouts of waking. ZT refers to Zeitgeber time.

Different from vehicle P < 0.05

Different from zolpidem P < 0.05