. 2008 Jan 1;31(1):34–44. doi: 10.1093/sleep/31.1.34

Table 3.

Duration of NREM Sleep and Number of NREM Bouts Observed per Hour Following Treatment with MDL100907, RO4368554, Zolpidem, and Vehicle

ZT	Vehicle	MDL100907, mg/kg			RO4368554, mg/kg			Zolpidem, mg/kg
ZT	Vehicle	0.3	1.0	3.0	1.0	3.0	10.0	10.0
NREM bout duration
19	1.05 ± 0.20	1.81 ± 0.62	0.87 ± 0.18	0.78 ± 0.10	0.93 ± 0.19	0.60 ± 0.18	0.84 ± 0.20	1.63 ± 0.31
20	1.01 ± 0.14	3.49 ± 0.58^a^b	3.63 ± 0.68^a^b	4.61 ± 1.08^a^b	1.81 ± 0.33	1.57 ± 0.13^b	2.29 ± 0.31^a	2.50 ± 0.41^a
21	1.26 ± 0.22	3.46 ± 0.54^a^b	2.93 ± 0.27^a	2.67 ± 0.47^a	1.26 ± 0.21	1.55 ± 0.15	1.87 ± 0.17	2.11 ± 0.42
22	1.01 ± 0.09	1.94 ± 0.38^a	1.72 ± 0.41	2.91 ± 0.47^a^b	1.14 ± 0.16	1.32 ± 0.22	1.32 ± 0.13	1.88 ± 0.33
23	0.82 ± 0.08	1.30 ± 0.13	0.93 ± 0.15	2.55 ± 0.59^a^b	0.82 ± 0.11	0.96 ± 0.15	1.01 ± 0.09	1.19 ± 0.19
24	1.09 ± 0.21	1.01 ± 0.22	1.49 ± 0.28	1.38 ± 0.30	1.07 ± 0.15	0.92 ± 0.14	0.76 ± 0.17	0.84 ± 0.15
Number of bouts
19	7.33 ± 1.64	5.78 ± 1.15^b	8.67 ± 0.85^b	8.67 ± 1.81^b	10.22 ± 1.27^b	8.22 ± 2.43^b	6.00 ± 1.17^b	17.67 ± 2.07^a
20	18.89 ± 2.38	10.22 ± 1.37^a	9.56 ± 1.51^a	9.11 ± 1.57^a	13.67 ± 1.86^a	17.11 ± 0.92	14.44 ± 1.43	13.56 ± 1.31^a
21	19.11 ± 2.25	9.78 ± 0.81^a^b	11.22 ± 0.89^a	11.78 ± 1.59^a	17.33 ± 2.49	16.56 ± 1.94	14.33 ± 2.32	16.22 ± 2.31
22	18.56 ± 2.25	12.33 ± 1.24^a	12.11 ± 2.21^a	11.44 ± 1.83^a	16.11 ± 2.84	15.44 ± 3.18	17.22 ± 2.50	12.67 ± 1.38^a
23	14.78 ± 2.48	12.11 ± 1.33	11.44 ± 2.21	12.33 ± 1.15	13.22 ± 1.71	17.33 ± 2.58	15.00 ± 2.24	14.56 ± 2.27
24	10.44 ± 1.23	13.11 ± 2.71	10.33 ± 1.36	11.89 ± 1.36	8.67 ± 2.01	11.00 ± 2.49	12.00 ± 3.09	10.67 ± 2.87

Data are expressed as mean ± SEM duration of non-rapid eye movement sleep (NREM), in minutes, and mean number (± SEM) of bouts of NREM sleep. ZT refers to Zeitgeber time.

Different from vehicle P < 0.05

Different from zolpidem P < 0.05