Table 4.
ZT | Vehicle | MDL100907, mg/kg |
RO4368554, mg/kg |
Zolpidem, mg/kg | ||||
---|---|---|---|---|---|---|---|---|
0.3 | 1.0 | 3.0 | 1.0 | 3.0 | 10.0 | 10.0 | ||
REM Bout Duration | ||||||||
19 | 0.32 ± 0.16 | 0.06 ± 0.06 | 0.19 ± 0.10 | 0.02 ± 0.02 | 0.28 ± 0.21 | 0.06 ± 0.06 | 0.30 ± 0.16 | 0.18 ± 0.08 |
20 | 0.67 ± 0.16 | 0.96 ± 0.24b | 1.06 ± 0.24b | 0.47 ± 0.19 | 0.71 ± 0.20b | 0.90 ± 0.16b | 0.83 ± 0.19b | 0.13 ± 0.10a |
21 | 0.83 ± 0.20 | 1.36 ± 0.20ab | 1.40 ± 0.25ab | 0.80 ± 0.22b | 0.56 ± 0.18 | 0.83 ± 0.16 | 0.77 ± 0.16 | 0.42 ± 0.09 |
22 | 0.94 ± 0.18 | 0.96 ± 0.22b | 0.80 ± 0.20 | 1.00 ± 0.28b | 0.53 ± 0.15 | 0.57 ± 0.24 | 0.87 ± 0.18 | 0.53 ± 0.14 |
23 | 0.25 ± 0.08 | 0.64 ± 0.26b | 0.92 ± 0.31ab | 0.69 ± 0.15b | 0.21 ± 0.14 | 0.44 ± 0.21 | 0.24 ± 0.14 | 0.16 ± 0.11 |
24 | 0.32 ± 0.20 | 0.33 ± 0.21 | 0.47 ± 0.24 | 0.54 ± 0.31b | 0.07 ± 0.04 | 0.04 ± 0.04 | 0.19 ± 0.10 | 0.02 ± 0.02 |
Number of REM Bouts | ||||||||
19 | 0.44 ± 0.24 | 0.11 ± 0.11 | 0.33 ± 0.17 | 0.11 ± 0.11 | 0.22 ± 0.15 | 0.22 ± 0.22 | 0.56 ± 0.34 | 0.78 ± 0.36 |
20 | 2.22 ± 0.70 | 1.22 ± 0.28 | 1.33 ± 0.29 | 1.22 ± 0.55 | 2.44 ± 0.69 | 2.78 ± 0.70 | 2.11 ± 0.56 | 0.56 ± 0.44 |
21 | 2.78 ± 0.66 | 3.22 ± 0.62 | 2.78 ± 0.78 | 1.89 ± 0.56 | 2.78 ± 0.83 | 3.67 ± 0.73 | 2.89 ± 0.79 | 2.22 ± 0.46 |
22 | 3.56 ± 1.25 | 2.89 ± 0.79 | 3.11 ± 0.86 | 2.00 ± 0.50 | 2.33 ± 0.78 | 1.44 ± 0.50 | 3.89 ± 1.12 | 1.89 ± 0.65 |
23 | 1.44 ± 0.85 | 1.33 ± 0.55 | 1.11 ± 0.48 | 2.56 ± 0.69 | 0.67 ± 0.37 | 0.78 ± 0.32 | 1.44 ± 0.82 | 0.44 ± 0.34 |
24 | 0.44 ± 0.24 | 0.44 ± 0.24 | 0.78 ± 0.36 | 1.11 ± 0.51 | 0.44 ± 0.24 | 0.56 ± 0.56 | 0.44 ± 0.24 | 0.11 ± 0.11 |
Data are expressed as mean ± SEM duration of rapid eye movement sleep (REM), in minutes, and mean number (± SEM) of bouts of REM. ZT refers to Zeitgeber time.
Different from vehicle P < 0.05
Different from zolpidem P < 0.05