Figure 2.

Impact of 5-hydroxytryptophan (5-HTP) on core body temperature (Tcore), wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep of B6.129S6-Il6^tm1Kopf (IL-6 KO) mice when administered at dark onset. Symbols are means ± SEM for 10-min (Tcore) or hourly (wakefulness, NREM, REM) values after intraperitoneal administration of vehicle (pyrogen-free saline, open symbols, thin lines) or 5-HTP (closed symbols, thick lines). Sample sizes are: 50 mg/kg, n = 6; 100 mg/kg, n = 10; 200 mg/kg, n = 10. The black bars on the x-axes denote the dark period of the light:dark cycle. Horizontal lines with asterisks identify 4-hour time blocks during which values differed statistically between conditions (P < 0.05).