Table 2.

Cell Proliferation and Phenotypes of BrdU-Positive Cells

	BrdU + cells	Ki-67 + cells	% BrdU/NeuN	% BrdU/S100β
CC	3437 ± 387	5094 ± 281	76.4 ± 2.5	7.3 ± 2.1
YC	1702 ± 220a	2557 ± 297a	59.4 ± 3.7a	5.5 ± 2.0
REMD	636 ± 131a,b	1104 ± 203a,b	53.3 ± 4.1a	6.8 ± 2.5
	F2,21 = 27.9***	F2,21 = 58.5***	F2,15 = 11.6***	F2,15 = 0.2

Cell proliferation was assessed by counting the total number of BrdU(5- bromo- 2′- deoxy-uridine)- or Ki-67-positive cells per dentate gyrus. Phenotypes of the surviving cells were determined by immunofluorescent triple labeling for BrdU, NeuN (neurons) and S100^β (glia) 3 weeks after the administration of BrdU. The percentages of BrdU-positive cells colabeled for either NeuN or S100^β are presented. Data are means ± SEM.

***P < 0.001, 1-way analysis of variance.

^aP < 0.01 vs cage controls, ^bP < 0.01 vs yoked controls, Bonferroni t-test.