A. Time course of effects of JHW007 on specific [125I]RTI-121 binding (top) and on locomotor activity in mice. x-axis, time after JHW007 injection. y-axis (top), specific [125I]RTI-121 binding expressed as a percentage of vehicle control; y-axis (bottom), horizontal activity counts per minute. Binding data are from 5–10 mice (top). B. Time course of effects of cocaine on specific [125I]RTI-121 binding (top) and locomotor activity in mice. x-axis, time after cocaine injection. Each point represents data from 5–13 (top) or 8 (bottom) mice, with error bars representing +1 SEM. From [18].