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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2007 Aug 9;75(1):2–16. doi: 10.1016/j.bcp.2007.08.007

Figure 16.

Figure 16

Relationship between percentage occupancy of the DA transporter in striatum and locomotor stimulant effects of cocaine, AHN 1-055, AHN 2-005 or JHW 007. Ordinates: difference between mean horizontal activity counts after drug and after saline. Abscissae: percent occupancy of DA transporter sites. For each drug, the solid line represents the linear regression of percent occupancy of the DA transporter and horizontal locomotor activity when the line is forced to intersect the origin, the point representing no occupancy and no effect. Note that the locomotor stimulant effects of cocaine are less strongly related to DA transporter occupancy than are the effects of AHN 1-055 and AHN 2-005. In contrast to each of the other drugs, the locomotor stimulant effects of JHW 007 were not related to its occupancy at the DA transporter. Modified from [18].